Anna Marstall

My research involves the design and synthesis of 14-membered sulfamide-containing macrocycles, using a build-couple-pair strategy to establish a macrocyclic framework from simple building blocks in only a few steps. The final cyclic scaffold contains three different nitrogen molecules around the ring framework, which allow for selective installation of electrophiles throughout the molecule and ultimately provide potentially tunable functionality towards protein interfaces. Upon development of a library of these macrocycles, we plan to carry out kinetic studies and reactivity profiling to determine the potential use of these molecules as cysteine-reactive chemical probes in elucidating complex biological pathways.